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KMID : 0981820070270040286
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Korean Journal of Laboratory Medicine
2007 Volume.27 No. 4 p.286 ~ p.291
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Panton-Valentine Leukocidin Positive Staphylococcus aureus Isolated from Blood in Korea
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Kim Jae-Seok
Park Jeong-Su
Song Won-Keun
Kim Han-Sung
Cho Hyoun-Chan
Lee Kyu-Man
Kim Eui-Chong
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Abstract
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Background:Panton-Valentine leukocidin (PVL) is a pore-forming toxin secreted by some Staphylococcus aureus strains and associated with skin and soft tissue infections; these strains are epidemiologically associated with current outbreaks of community-acquired methicillin-resistant S. aureus (MRSA) and with necrotizing pneumonia in healthy adults in USA and Europe. This study was performed to investigate the presence of PVL-positive S. aureus and the significant infections known to be caused by this organism.
Methods:A total of 573 strains of S. aureus blood isolates at university-affiliated hospital during 2002 to 2005 were selected. The presence of PVL was investigated using PCR. Additional 12 staphylococcal toxin genes were also examined in PVL-positive S. aureus strains, and MRSA isolates were typed for the staphylococcal cassette chromosome mec (SCCmec).
Results:PVL genes were detected in 5 (0.9%) of 573 S. aureus strains, including 1 MRSA and 4 MSSA. The PVL-positive MRSA isolate was SCCmec type IV, and no other staphylococcal toxins were detected. The median age of the patients infected with PVL-positive S. aureus was 36 yr. Three cases of bacteremia were preceded by skin and soft-tissue infections.
Conclusions:Bacteremia caused by PVL-positive S. aureus strain were detected in 5 patients in Korea, and some of the patients were associated with severe skin and soft-tissue infections. In addition, the PVL-positive MRSA strain of SCCmec type IV, a characteristic of community-acquired MRSA isolates in USA and Europe, also exists in Korea, and can cause the severe infections known to be associated with this organism. (Korean J Lab Med 2007;27:286-91)
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KEYWORD
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Staphylococcus aureus, MRSA, Panton-Valentine leukocidin, Toxin, SCCmec, Soft tissue infection
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